Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma
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چکیده
منابع مشابه
Intratumoral aromatase as a prognostic factor in human breast carcinoma.
Intratumoral aromatase activity (AA) was measured in 145 samples of human primary breast carcinoma using the tritiated water release assay which quantifies the tritium lost to water during the aromatization of 1 beta-[3H]androstenedione to estrone. Significant AA was detected in 91/145 (63%) tumors. The possibility of a relationship between AA and a variety of clinical prognostic factors such a...
متن کاملIdentification of Oestrone Sulphatase Inhibitors in Breast Cyst Fluid: a New Treatment for Breast Cancer
Introduction Oestrogens play an important role in the development of breast cancer. Oestrone sulphate is a major source of active oestrogens in the breast, being converted to oestrone by oestrone sulphatase. Oestrone is then converted to oestradiol, a potent oestrogen strongly implicated in the development of breast cancer, by the enzyme 1713-hydroxysteroiddehydrogenase. In vitro oestrone sulph...
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BACKGROUND The prognostic effect of tumor infiltrating CD8+ cytotoxic lymphocytes (CTLs) in breast cancer is controversial. We analyzed the association between CD8+ CTLs and survival of untreated node-negative breast cancer patients. MATERIAL AND METHODS CD8+ CTLs infiltrate was evaluated by immunostaining in a cohort of 332 node-negative breast cancer patients with a median follow-up of 152 ...
متن کاملDemethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma.
PURPOSE Urokinase (uPA) is expressed in a number of highly invasive malignancies including breast cancer. Because production of uPA is associated with breast cancer progression and can serve as a useful prognostic marker, the purpose of this study was to examine the role of uPA promoter methylation as an indicator of uPA production in breast cancer patients. EXPERIMENTAL DESIGN We examined th...
متن کاملTumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination.
PURPOSE Multiphoton-based intravital imaging has shown that invasive carcinoma cells in mouse and rat mammary tumors intravasate when associated with perivascular macrophages, identifying a potential tumor microenvironment of metastasis (TMEM). We define TMEM as the tripartite arrangement of an invasive carcinoma cell, a macrophage, and an endothelial cell. The aim of this study was to determin...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1994
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1994.101